A STUDY ON THE BACTERIAL DISSEMINATION AND EXPERIMENTAL PATHOLOGY OF SALMONELLA PARATYPHI – AN INFECTION IN WHITE MICE

Hassan Znad Al-Joboury, Khalil

	A STUDY ON THE BACTERIAL DISSEMINATION AND EXPERIMENTAL PATHOLOGY OF SALMONELLA PARATYPHI – AN INFECTION IN WHITE MICE
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 5, Issue 3, 2007, Pages 23-30
Author
Khalil Hassan Znad Al-Joboury
Abstract
Background: Paratyphoid infection remains an important public health problem with marked host specificity for humans or higher primates but not naturally virulent for mice except that using high inoculum of the paratyphoid bacilli. Objective: 1. Study the bacterial dissemination through the organs of white mice. 2. Study the pathological changes associated with this experimental disease process Methods: One LD50 of the microorganism corresponded to 8x107 bacterial Cell/ml. However 10LD50 doses were intraperitoneally used for mice to produce extensive disease process in mice. Following inoculation of mice the course bacterial dissemination and pathological lesions were studied at specific intervals and for 3 days post inoculation. Result: The microorganisms were persistent in the spleen and liver for 21 and 17 days postinoculation respectively, where as the microorganisms persisted in the mediastinal lymph nodes and lungs for 9 days and kidney and heart blood for 5 days postinoculation. The main pathological lesions were initiated as a mild infiltration of neutrophils and edema in the spleen liver and lymph node the neutrophils iflteration will be gradully replaced by mononuclear cell infiltration and finally with fibroblasts proliferation. Conclusion: The Salmonella paratyphi-A is of lower pathogenicity and virulence for white mice, through their dissemination in organs of white mice and associated pathological findings. Keywords: Salmonella paratyphi-A infection white mice
Keywords
Salmonella paratyphi; A infection white mice

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