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ASSOCIATION BETWEEN SERUM COPPER, OXIDIZED HDL AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN RELATION TO MICROALBUMINURIA | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 5, Issue 3, 2007, Pages 39-46 | ||
| Authors | ||
| Ghassan A. Al-Shamma; Hashim M. Hashim; Mohammed A. Latif Al Bayati | ||
| Abstract | ||
| Background: diabetes mellitus (DM ) is associated with a markedly increased mortality rate from cardiovascular and renal disease, not explainable by traditional risk factors. Although data are not yet conclusive, oxidative stress, dyslipidemia, glycemic control and possibly lipid peroxidation has been increasingly implicated in the pathogenesis of diabetic micro- and macrovascular disease. Little is known, however, about the role of copper in type 2 diabetes. Aim: The present study includes measurement of free radical activity marker (lipid peroxides expressed as malondialdehyde MDA) along with the serum and urine copper, serum lipid profile, glycated haemoglobin (HbA1c) in addition to urinary protein : creatinine ratio in 55 patients with type 2 DM (T2DM) . Results: The patients were divided according to the spot urine albumin excretion (urinary albumin ug / mg creatinine ratio) into two groups:- microalbuminurics & normoalbuminurics. The results were compared with those obtained from 37 age-matched apparently healthy control subjects. There was a significant elevation in serum malondialdehyde MDA , the percentage of oxidized non high-density lipoprotien (ox. non-HDL%) and serum copper with a significant reduction in the percentage of oxidized high-density lipoprotien (ox. HDL%) in the diabetic patients (particulary in the microalbuminurics) as compared with the control subjects. Serum MDA was significantly and positively correlated with serum copper in microalbuminurics and HbA1c% in both diabetic groups. LDL size index was significantly increased in microalbuminuric T2DM patients as compared to the controls and normoalbuminurics indicating smaller LDL size in the diabetics in general and in microalbuminuric in particular. Conclusion: the results of present study suggest an increase in free radical activity , dyslipidaemia and serum copper level favoring atherosclerotic state more in poor glycemic control in type 2 DM particularly in microalbuminurics. The suggested mechanisms underlying these events are discussed. Key words: Copper, lipid peroxides, diabetes mellitus., Microalbuminuria | ||
| Keywords | ||
| copper; lipid peroxides; diabetes mellitus; Microalbuminuria | ||
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