- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
OXIDIZED LIPOPROTEINS IN HYPERTENSIVE PATIENTS ON DIFFERENT MODALITIES OF TREATMENT. | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 5, Issue 3, 2007, Pages 57-64 | ||
| Authors | ||
| Ghassan A. Al-Shamma; Abdul Rahman A. Al-Bazzaz; Faisal Gh. Al-Rubaey | ||
| Abstract | ||
| Background:In addition to hypercholesterolaemia and smoking, hypertension, a chronic disease with many cardiovascular complications, is one of the major risk factors for cardiac ischemia, and the main risk factor for cerebrovascular disease. Recent studies have demonstrated some unwanted effects on lipid profile and trace element metabolism caused by antihypertensive drugs. Aim: To elucidate the role of oxidative stress and lipid peroxidation in hypertension and the effect of different medical therapies on these parameters. Subjects and methods: The present study included measurement of serum lipid profile, total lipid peroxidation, oxidized HDL ( Ox-HDL), and urinary protein in 69 patients aged 30-70 years . They were three groups according to the type of therapy: (atenelol, captopril & no pharmacological antihypertensives, NPAHT). The results were compared with those of 45 apparently healthy controls (age range = 30-66 years). Results: showed a significant elevation in serum malondialdehyde (MDA) and the percentage of oxidized non high-density lipoprotein (OX.non-HDL %) with a significant reduction in the percentage of oxidized high-density lipoprotein (OX.HDL %) as compared to the controls. The disturbance in the oxidant / antioxidant balance happened despite the treatment and blood pressure control showing different pictures with different modalities of treatment, being the best with the captopril. Conclusion: Hypertensives on different modalities of therapy experienced dyslipidemia, (High triglycerides and small dense LDL particles) and oxidative stress presented by changes in the percents of oxidized lipoproteins especially in those on NPAHT. The suggested mechanisms underlying these events are discussed. Keywords: hypertension, lipid peroxidation, ox-HDL. captopril , atenelol | ||
| Keywords | ||
| Hypertension; lipid peroxidation; HDL; captopril; atenelol | ||
|
Statistics Article View: 167 PDF Download: 27 |
||