CLINICAL PLUS COLOR DOPPLER ASSESSMENT OF BENIGN AND MALIGNANT BREAST DISEASES

A. Abdul Hassan, Bashar; Abdul Rasoul Hatam, Hikmat

	CLINICAL PLUS COLOR DOPPLER ASSESSMENT OF BENIGN AND MALIGNANT BREAST DISEASES
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 5, Issue 3, 2007, Pages 73-80
Authors
Bashar A. Abdul Hassan; Hikmat Abdul Rasoul Hatam
Abstract
Background: Tumor growth and metastases require the development of new vessels (angiogenesis), and the extent of angiogenesis predicts metastases and correlate with early death. Recently developed color Doppler mapping can detect the tumor flow signals in breast cancer and help to distinguish it from benign lesions. Objective: Evaluation of differences between the blood supply in benign and malignant breast lesions by the use of color Doppler image assessment of the lesions vascularity. Method: Clinical assessment, ultrasound examination and color Doppler mapping were done for 83 female patients with breast lesions. The following flow data analyses were undertaken; presence or absence of color Doppler signal, number of blood vessels, architectural arrangement and the maximum systolic velocity of blood vessels in the lesions and around it. Results: Histopathological reveals that 21 cases had carcinoma of the breast and 62 had benign lesions. 27 patients provisionally diagnosed as having malignant lesions; of them 15 cases were truly malignant (sensitivity: 71.5%) and 56 benign one; of them 50 lesions were truly benign (specificity: 80.6%). An increasing number of blood vessels found in malignant lesions; (85.7%) showed more than 3 vessels in a given lesion, while this figure found only in (8%) of benign lesions. For a cutoff of more than 3 vessels sensitivity and specificity are (85.7%), (91.9%) subsequently. Architectural differences in the form of penetrating central neoplastic vessels were present in 18 (85.7%) of the malignant lesions with sensitivity (90.4%), while only in 3 (6.1%) of the benign lesions with specificity (93.8%). The maximum systolic velocity of tumor vessels showed an increasing velocity in malignant lesions, for a cutoff more than 15 cm/s the sensitivity was (90.4%) and specificity was (91.8%). Combination of the three parameters gave (90.4%) sensitivity and (96.7%) specificity. Conclusion: Color Doppler imaging considered as an adjuvant primary investigation tool in addition to the ultrasound examination in improving differential diagnosis of breast lesion. Keywords: Color Doppler, Breast diseases, Benign, Malignant.
Keywords
Color Doppler; Breast diseases; Benign; malignant

Statistics Article View: 54 PDF Download: 39