EFFECT OF TAMOXIFEN ON ANTIOXIDANT VITAMINS, URIC ACID AND GAMMA-GLUTAMYL TRANSPEPTIDASE IN BREAST CANCER PATIENTS

S.H.Al-Khalidy, Huda; H.N.Al-Rubae, Salwa; H.Al-Khayat, Tariq

	EFFECT OF TAMOXIFEN ON ANTIOXIDANT VITAMINS, URIC ACID AND GAMMA-GLUTAMYL TRANSPEPTIDASE IN BREAST CANCER PATIENTS
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 6, Issue 1, 2008, Pages 52-59
Authors
Huda S.H.Al-Khalidy; Salwa H.N.Al-Rubae; Tariq H.Al-Khayat
Abstract
Background: Many research works clearly indicate that free radical and reactive oxygen species play a major role in the etiology and development of breast cancer in postmenopausal women. Available literatures suggest that tamoxifen is a potent suppressor of lipid peroxidation in experimental animals. Objectives: The objective of this study is to understand the antioxidant status and oxidative stress in breast malignancy of postmenopausal women before and after treatment with tamoxifen. Methods: Eight to nine months’ tamoxifen therapy (10 mg twice daily) in 19 postmenopausal women was conducted. Serum levels of vitamin A, E & C were determined; also uric acid& GGT were determined. The results were correlated with serum MDA levels. The results were compared with those in patients with breast benign tumors (N=21) and control group (N=23). Results: A highly significant decrease in antioxidant vitamins levels in breast cancer patients were noticed (P<0.001) compared with those of benign tumor. Also a significant increase in uric acid, GGT, and MDA levels was observed in cancer patients (P<0.01). There was a significant increase in antioxidant vitamins (P<0.01) and significant decrease in uric acid, GGT and MDA levels in cancer patients after treatment with tamoxifen. Conclusion: The results suggest that tamoxifen exerts a significant effect on the rate of lipid peroxidation and a major improvement in antioxidant status
Keywords
Breast cancer; Tamoxifen; Antioxidant Vitamins; GGT

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