HISTOLOGICAL EFFECT OF MELATONIN HORMONE ON ADULT RAT'S PROSTATE

A. Eleiwe, Samia

	HISTOLOGICAL EFFECT OF MELATONIN HORMONE ON ADULT RAT'S PROSTATE
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 6, Issue 1, 2008, Pages 81-88
Author
Samia A. Eleiwe
Abstract
Background: The prostate is the largest of the accessory glands of the male reproductive tract. Its secretion serves as a diluent and vehicle for transport of sperms from male to female, so its function is very important for the normal fertility. Melatonin is the basic neuro-hormone of the pineal gland, regulates the sexual and reproductive activities in all mammals including man. Objective: This work aimed to study the effect of different doses of dietary melatonin on adult rat's prostate, "histologically". Methods: Melatonin was supplied to adult Wister albino rats, for successive 30 days. Rats were divided into 6 groups. Group I was the control. Group II, III, IV, V and VI were given (mixed with their diet) a daily dose of 125, 250, 500, 750 and 1000 µg / kg body weight, respectively. The dietary melatonin was supplied to rats mixed with their food. After the last day of treatment, animals were killed under effect of anesthesia; prostate was removed for histological study. Results: The results showed significant beneficial effects on prostate by normal therapeutic dosages, whereas significant damaging effects were seen with further stepping up doses. Conclusion: Dietary melatonin has good effects on the rat's prostate within therapeutic doses, whereas it had highly damaging changes in overabundance.
Keywords
prostate; Melatonin; Fertility

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