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POSSIBLE ASSOCIATION OF HLA CLASS I AND II MOLECULES WITH ULCERATIVE COLITIS IN IRAQI PATIENTS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 6, Issue 1, 2008, Pages 108-113 | ||
| Author | ||
| Ahmed A .Al-Hassan | ||
| Abstract | ||
| Background: The etiology and pathogenesis of ulcerative colitis has not yet been elucidated. However, attention has been brought to the belief that a genetic factor plays a crucial role in the development of the disease. Objectives: This study was established to shed light on the possible association of HLA class I and class II antigen with ulcerative colitis. Methods: The study included 105 subjects. It comprised of 35 ulcerative colitis patients and 70 apparently healthy controls. Lymphocytotoxicity assay has been used to assess HLA-typing. Results: Comparison between ulcerative colitis patients and healthy control showed positive significant associations of HLA –B14, B27 and DR52 antigens with patients, however, only B27 maintained a significant P value after adjustment. Meanwhile the frequencies of HLA -B35, B41 and Cw6 were decreased in patients when compared with control group. Conclusions: These findings demonstrated that HLA –B14, B27 and DR52 might play a role in ulcerative colitis susceptibility, while HLA-B35, B41 and Cw6 may confer protective effects against ulcerative colitis. | ||
| Keywords | ||
| Ulcerative Colitis; Genetic factors; HLA | ||
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