OXIDATIVE STRESS AND METABOLIC CONTROL IN TYPE 2 DIABETIC PATIENTS

Naji Kassim, Mohammed

	OXIDATIVE STRESS AND METABOLIC CONTROL IN TYPE 2 DIABETIC PATIENTS
AL-TAQANI
Article 1, Volume 24, Issue 4, 2011, Pages 70-78
Author
Mohammed Naji Kassim
Abstract
Objectives: The aim of this study is to investigate some oxidative stress related parameters in type 2 diabetes mellitus (T2DM) and to determine the effect of glycemic control on these parameters. Methods: Serum lipid peroxidation product (MDA) and glucose levels and the activity of superoxide dismutase(SOD), catalase(cat) and HbA1c ratio in erythrocytes were assessed. In addition serum levels of copper, zinc and iron were also measured using flame atomic absorption spectrophotometer Results: Erythrocyte -SOD and CAT activities and serum zinc level in type 2 DM(T2DM) were significantly lower than those of the control subjects (p < 0.001). MDA level in type2DM was significantly higher than the control subjects (p < 0.001). During poor glycemic control ,on the other hand, serum copper showed no significant differences . A statistically negative correlation (p < 0.01) was found between MDA generation and SOD, CAT and serum zinc and a significant positive correlation with serum copper and glucose. Serum iron showed no significant positive correlation with MDA in T2DM patients .A statistically negative correlation (p<0.01) was found between HbA1c with SOD, CAT and serum zinc. A statistically positive correlation was found between HbA1c with MDA, serum copper and glucose (p< 0.01). Conclusion: There is an association between oxidative stress and metabolic control in diabetic patients.

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