Evaluation of some Liver Function Tests During Different  Gestational  Period

H. Al-Hamdani, Ahmed; S. Al-Doski, Fadhila

doi:10.33899/rjs.2012.29404

	Evaluation of some Liver Function Tests During Different Gestational Period
Rafidain Journal of Science
Article 5, Volume 23, Issue 1, 2012, Pages 44-51 PDF (0 K)
DOI: 10.33899/rjs.2012.29404
Authors
Ahmed H. Al-Hamdani; Fadhila S. Al-Doski
Abstract
This study was designed to assess the effect of pregnancy on liver function tests (LFTs) and to identify the variations between these LFTs during different gestational period. The present study include seven parameters: serum liver enzymes (AST, ALT, ALP, AST/ALT ratio) and bilirubin (total, direct and indirect) had been measured in blood of 50 healthy nonpregnant women, their age was ranged between (17-40) years as a control group and in 150 apparently healthy pregnant women their aged between (16-41) years. Pregnant women were divided into three subgroups according to their gestational period: 1st, 2nd and 3rd trimesters (50 pregnant for each trimester of pregnancy). The results recorded a non significant difference in AST activity in all trimesters compared with control group, while serum ALT activity showed a significant reduction during pregnancy trimesters as compared with control group. The serum ALP activity show a significant increase as gestational period progress. However, the result of AST/ALT ratio showed no significant difference with the increase in the gestational period. Finally, serum total, direct and indirect bilirubin were all non significantly difference in all trimesters when compared with control (except the significant decrease in the comparison of total bilirubin in the 3rd trimester with control group).
Keywords
Pregnancy and liver function tests

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