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INCREASED EXPRESSION OF ESTROGEN RECEPTORS AT THE MATERNO-FETAL INTERFACE IN PATIENTS WITH RECURRENT PREGNENCY LOSS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 7, Issue 1, 2009, Pages 55-60 | ||
| Authors | ||
| Aml Hindi Al-Falahi; Baqer Al-Obaidi; ; Nidhal Abdul-Mohaymen | ||
| Abstract | ||
| Background: Estrogen hormone has been implicated in the pathogenesis of different genital tract pathologies and in counteracting the progress of normal pregnancy. Objective: Localization and semi-quantization of estrogen receptors at the materno-fetal interface in patients with recurrent pregnancy loss (RPL). Methods: Immunohistochemistry analysis of estrogen receptors using paraffin embedded sections of curate samples obtained from 40 women, who where divided into three groups: 24 women with RPL, 10 women with abortion for the first time, and 6 women with induced abortion. Results: The mean value of the expression of estrogen receptors was (71.2 ± 2.3), which is significantly higher than that of the second group (52.2 ± 3.2), and the third group (43.7 ± 4.2), (p=0.001). Conclusion: High expression of estrogen receptors in women with RPL may give a clue to its prominent role in the pathology of pregnancy loss. Key wards: Estrogen receptor, RPL. | ||
| Keywords | ||
| Estrogen Receptor; RPL | ||
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