MINERAL HOMEOSTASIS IN PREECLAMPSIA

Hovthy Al-Khayat, Tariq; M. Al-Bayati, Maha; Gh. Al-Rubaye, Faisal

	MINERAL HOMEOSTASIS IN PREECLAMPSIA
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 7, Issue 2, 2009, Pages 4-11
Authors
Tariq Hovthy Al-Khayat; Maha M. Al-Bayati; Faisal Gh. Al-Rubaye
Abstract
Background: Preeclampsia is a form of high blood pressure manifested during pregnancy, it is a common major complication causing significant morbidity and mortality; however, its etiology is unknown. Moreover, data on mineral homeostasis and on cation pattern during pregnancy are conflicting. Also, the status of ionized calcium and magnesium during pregnancy and its complication preeclampsia have not been described adequately. Objective: to demonstrate the pattern of minerals during preeclampsia with respect to normal pregnancy. Subject and methods: the present study is a cross-sectional case-control study includes measurement of minerals (calcium and magnesium) in 60 patients with preeclampsia. They are classified into two groups according to gestational age: o Preeclamptics in the second trimester G1: (n=30). o Preeclamptics in the third trimester G2: (n=30,). The results are compared with 60 apparently healthy pregnants controls. They are classified according to gestational age into two groups: o Pregnants in the second trimester G3: (n=30). o Pregnants in the third trimester G4: (n=30). Results: show that serum corrected calcium and serum magnesium are significantly reduced in preeclamptics when compared with normal pregnants. In addition, there was a reduction in free calcium and free magnesium that was accompanied by a significant high elevation of the ratio between ionized calcium to ionized magnesium. Conclusion: preeclamptics (in different gestational age groups) have altered mineral status when compared with healthy pregnants matched with their age and gestational age. Key words: preeclampsia, calcium, magnesium.
Keywords
Preeclampsia; Calcium; magnesium

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