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ULTRA STRUCTURAL STUDY OF CARBOXYLESTER HYDROLASES ACTIVITY IN THE INTERNEURON OF THE MAMMALIAN SPINAL CORD | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 7, Issue 2, 2009, Pages 59-66 | ||
| Author | ||
| Ali Abdul-Sattar Abdul-Rhman | ||
| Abstract | ||
| Background: Neurosciences mainly focused on the enzymatic pattern of the neurons, however, in this study the demonstration of certain carboxylaser hydrolases (Alph naphthyl butyrate esterases) activity in the Intrinsic spinal networks neurons (central pattern generator) was performed. Objective: Interneurons or Renshow cells assume autoinhibitor functions, which dampens the a-motoneurons through negative feedback circuit, in addition to that they receive an input from higher centers through which it modify reflex responses to peripheral stimuli by facilitating or inhibiting different populations of interneurons, however, this issue modulates the performance of specific movement performed by a-motoneurons. Materials and methods: α – naphthyl butyrate used as a broad spectrum substrate in treating minced tissue block of gray matter of the spinal cord in the Rabbit prior to their traetment with the usual way to be examined lateron with the electron microscopy . Result: Reactivity was clearly evident in a form of deep stained granules in the nuclear matrix ,mitochondera and ,RER , and in certain prenuclear region ,however, the reactivity was varied in the mitochondrea in different neurons examined. Conclusion: Recently the term, central pattern generators was used, which address the Intrinsic spinal networks of interneurones that control the timing and pattern of the muscle activity underlying locomotion in mammals,however the effect of the higher centers that modulates the type & tone of movement through those neurons elucidate function which was varied from excitatory-inhibitory, flexor-extensor. The reactivity of those enzymes and their different isoformes that might have an effect on the molecular and genetic pattern of neurotransmitres were discussed in this study . Keywords: Interneurons,Central pattern generator, Alpha naphthyl butyrate,esterase, Spinal cord | ||
| Keywords | ||
| Interneurons; Central pattern generator; Alpha naphthyl butyrate; esterase; Spinal cord | ||
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