- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Topical treatment of atopic dermatitis by silymarin | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 17, Issue 3, 2005, Pages 56-61 | ||
| Author | ||
| Tagreed Altaei | ||
| Abstract | ||
| Background: Atopic dermatitis is a chronic inflammatory disease that causes eczema, rashes, and itching. It is most common in younger people & adolescence. Recurrent relapses are a characteristic feature of atopic eczema. Anti-inflammatory therapy of exacerbations is aimed to control effectively disease activity and permit a return to basic dermatological therapy as soon as possible. Oxidative stress & inflammatory responses are thought to be responsible for the pathogenesis of atopic dermatitis. Silymarin is a polyphenolic flavonoid derived from the seed of milk thistle (Silybum marianum (L.) Gaertner) that has anti-inflammatory, antioxidant and cytoprotective effect. The aim of this study was to evaluate the anti-inflammatory effect of topical preparation of silymarin in atopic dermatitis. Patients & method: Forty-three patients with atopic dermatitis (26 female, 14 male, 3 - 34 years old) were participated in the single blind, placebo controlled, 8-week trial. Of these, 10 patients were treated with 0.05 %, 10 patients were treated with 0.1 %, 10 patients were treated with 0.2 % topical preparation of silymarin, twice daily. The other 10 patients were received placebo twice daily. Results: There was a statistically significant improvement. A statically significant was seen in mean total body surface area involvement over time. Mean total body surface area was 25.675% at baseline & decreased to 1% at 2-4 week. Silymarin ointment was proven to act rapidly, to be highly effective, excellent improvements in pruritis, erythema, & skin irritation were noted in the patients who received 0.1 % & 0.2 % silymarin ointment topical treatment in comparison with the control group. Conclusion: Topical treatment of silymarin is more effective, safe & may represent a breakthrough drug in the manegment of atopic dermatitis. | ||
| Keywords | ||
| Atopic Dermatitis; Silymarin | ||
|
Statistics Article View: 165 PDF Download: 106 |
||