Repeat breeders are one of the most important reproductive disorders in buffaloes, and consider as a main source of economic losses in these animals. The aim of this study was to compare different kinds of treatments and choose the most affective one. Fourty nine repeat breeders buffaloes were divided into 4 groups according to the type of treatment, The first group of 15 buffaloes were given Metricure® (cefapirin) intrauterine injection, the second group of 12 buffaloes were treated by intrauterine injection of Lugols Iodine 1% (50ml). The third group of 11 buffaloes were given oxytetracycline intrauterine (4gm + 20 ml distil water), the fourth group of 11 buffaloes were left as control group. The percentage response were (66.6, 75, 72.7, 54.5)% for 1st,2nd,3rd and 4th groups respectively. Open days were (173.5±13.31, 181.6±11.25, 189±10.93, 216.7±18.29) for the all groups respectively, there was a significant difference (p<0.01) between 1st group and the 2nd,3rd &4th groups while there is no significant difference (p<0.01) between 2nd & 3rd groups and there was significant difference between 2nd & 3rd groups with the 4th group. It was concluded that treatment with Lugol's Iodine gives the best results as compared with antibiotics therapy. Treatment with Metricure® (cefapirin) showed the shorter open days which is an important index in reproductive performance in buffaloes |