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Synthesis and characterization of benzylidene- [1,3,4]thaidiazol -2-yl-amine | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 3, Issue 1, 2006, Pages 32-39 | ||
| Author | ||
| Al-Kaddimy H. A. Ahmed | ||
| Abstract | ||
| This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiff’s base. The principle synthesis of these compounds was to involve three steps: First : by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide dissolved in anhydrous ethanol to yield 2-amino-5- mercapto-1,3,4-thiadiazole. Second : by thermal cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-1,3,4-thiadiazole. Third : Schiff’s base formation by reflux of aromatic aldehyde with 2-amino-5-R-1,3,4-thiadiazole in the presence of ethanol. The chemical structures of all prepared compounds were confirmed by spectral data (UV-visible and IR spectroscopy) tables (1, 2, and 3). | ||
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