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POSSIBLE ROLE OF IL-1-α AND TNF-α IN BREAST CANCER | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 8, Issue 1, 2010, Pages 11-17 | ||
| Authors | ||
| Eman Sh. Al-Obeidy; Leen K. Mustafa; ; a Ghany Hussien; Nidhal Abdul Muhymen; Ahmed A .Al-Hassan | ||
| Abstract | ||
| Background: Cytokines have been used as biomarkers in research for prognosis and have been associated with symptoms and adverse outcomes in multiple conditions, including breast cancer. Objectives: To estimate the concentration of IL-1-α and TNF-α in serum of breast cancer (BC) patients compared with control groups and to detect if there is association of serum levels of these interleukins with disease development. Subjects and Methods: The levels of IL-1-α and TNF-α were measured by ELISA method in sera of 45 BC patients, 12 patients with benign breast lesions and 23 apparently healthy controls. Results: Present study was demonstrated that IL-1-α and TNF-α levels were significantly elevated in serum of BC patients as compared with controls (p<0.001), this elevation were significantly associated with poor prognostic factors including advanced stage and estrogen and progesterone receptors-negative status. Conclusions: Evaluation the serum level of IL--α1and TNF-α may be helpful as predictive non-invasive tests for tumor development in breast cancer patients. Keywords: Breast cancer, IL--α1, TNF-α. | ||
| Keywords | ||
| Breast cancer; TNF | ||
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