THE EFFECTS OF LOW AND HIGH DOSE OF URANYL NITRATE ON HORMONAL ANALYSIS AND SOME BLOOD PARAMETERS IN RATS

Hana,; Ismail Dhahir, A

	THE EFFECTS OF LOW AND HIGH DOSE OF URANYL NITRATE ON HORMONAL ANALYSIS AND SOME BLOOD PARAMETERS IN RATS
AL-TAQANI
Article 1, Volume 23, Issue 5, 2010, Pages 8-13
Authors
; a Ismail Dhahir
Abstract
In this study the effects of low dose (75 mg/ kg/ bw) and high dose (100 mg/ kg/ bw) of uranyl nitrate (UN) on hormonal analysis and some blood parameters were investigated. Sixty male mature Sprague–Dawlley rats were divided into three equal groups. 1. Control group A (adminstrated normal Saline ) 2. Low dose group B (administrated 75 mg /kg/ bw of uranyl nitrate) 3. High dose group C (administrated 100 mg /kg/ bw of uranyl nitrate). The route of administration was oral intubations for 53 days. The results have recorded the following: 1. Low and high dose of uranyl nitrate treatment cause a significant (P<0.05) increament of alkaline and acid phosphatase enzyme in blood stream 2. Low and high dose of uranyl nitrate treatment cause a significant (P<0.05) increament of testosterone hormone. 3. Low dose of uranyl nitrate treatment cause a significant (P<0.05) elevation of total white blood cells ( WBCs ) count, while high dose of uranyl nitrate treatment cause a significant (P<0.05) decrement of total WBCs count 4. Low dose of uranyl nitrate treatment cause a significant (P<0.05) increament of Lymphocyte percentage, while a significant (P<0.05) decrement was found in nentrophil percentage 5. Low dose of uranyl nitrate treatment cause a significant (P<0.05) decreament of neutrophil percentage, while high dose of uranyl nitrate treatment restore the neutrophil percentage in blood. From this study we conclude that uranyl nitrate treatment caused a marked effect on some enzymes concentrations, hormonal level in blood stream and on total and differential count of WBCs.

Statistics Article View: 54 PDF Download: 14