The relationship between Helicobacter pylori CagA and antral Gastrin (G) and somatostatin (D) cells in chronic gastritis patients

H. Salman, Amal

	The relationship between Helicobacter pylori CagA and antral Gastrin (G) and somatostatin (D) cells in chronic gastritis patients
AL-TAQANI
Article 1, Volume 23, Issue 5, 2010, Pages 135-144
Author
Amal H. Salman
Abstract
Objectives: Investigate the relationship between in situ expression of Helicobacter pylori CagA and the numbers of gastrin (G-cells) and somatostatin (D-cells) in gastric tissue investigated by immunohistochemical analysis. Methods: The paraffin embedded sections for antral mucosal biopsy specimens were examined using in situ hybridization technique with probe specific for CagA and investigated the expression of gastrin (G-cells) and somatostatin (D-cells) proteins by immunohistochemistry using specific monoclonal antibodies. Results: The number of G-cells per gastric gland was significantly higher in patients infected with H.pylori compared with uninfected patients or normal mucosa subjects(p<0.01). The number of D-cells was significantly higher in uninfected patients and normal mucosa subjects patients compared with H.pylori infection (p<0.01). In patients with chronic gastritis the presence of CagA were associated with higher expression of G cell and not influence to D cell. Conclusions: the results of this study was strongly suggest that H.pylori infection induction protein expression of G-cell and reduction of protein expression of D-cells and the H.pylori positive CagA might play a role in up-regulation of the expression of G- cells but not effects on the expression of D-cells. The resulting relative hypofunction of the inhibitory action of D-cells against G-cells might be one of the reasons for the existing hypergastrinemia.

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