Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats, C., Hashim Zalzala, M., Abdulrahman Hassain, S. (2007). Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats.. , 4(1), 47-54.
Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats; Munaf Hashim Zalzala; Saad Abdulrahman Hassain. "Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats.". , 4, 1, 2007, 47-54.
Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats, C., Hashim Zalzala, M., Abdulrahman Hassain, S. (2007). 'Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats.', , 4(1), pp. 47-54.
Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats, C., Hashim Zalzala, M., Abdulrahman Hassain, S. Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats.. , 2007; 4(1): 47-54.

Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats.

Al-Mustansiriyah Journal for Pharmaceutical Sciences
Article 1, Volume 4, Issue 1, 2007, Pages 47-54
Authors
Comparative Study of the Effects of Enzyme Inhibitors and Inducers on Serum and Tissue Availability of Thiamine After Single Oral Dose of the Pro-drug Benfotiamine in Rats; Munaf Hashim Zalzala; Saad Abdulrahman Hassain
Abstract
Thiamine is known to have an important role in the protection of different types of cells
and tissues against the damage produced by many drugs and toxins. The most important
problem limiting the clinical applications of this approach is the poor absorption and
bioavailability of thiamine from the sites of administration, a problem which can be
solved by the use of the lipid soluble pro-drug for thiamine, benfotiamine. Accordingly,
this project was designed to evaluate the serum and tissues availability of thiamine in rats
after the administration of single oral dose of benfotiamine compared with that produced
by the same oral dose of thiamine, in addition to study the effects of enzyme inducers and
inhibitors in this respect utilizing HPLC technique. According to the results obtained in
this study one can conclude that thiamine availability after administration of
benfotiamine was more in serum, liver, kidney while in the brain more time may be
required to reach maximum level.
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