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Histopathological observations about the effect of pure nicotine in different doses on ovaries of albino rats | ||
| Kufa Journal For Veterinary Medical Sciences | ||
| Article 1, Volume 2, Issue 2, 2011, Pages 30-36 | ||
| Authors | ||
| Shatha Atta Al; | ||
| Abstract | ||
| Abstract: The aim of present study was detected the effect of pure nicotine on the histological structure of rat ovaries cortex . In this study was used (24 ) good healthy adult female rats were divided into three groups each group includes (8) animals : The 1st. experimental group was injected (4) mg of pure nicotine subcutaneously ( s/c ) twice daily .The 2 nd. experimental group was injected ( 8 ) mg of pure nicotine ( s/c ) twice daily , while the 3 rd. control group was injected physiological normal saline (0.9 NaCl 2). The experimental period was ( 8 ) weeks . The histopathological observations in the 1st. experimental group was appeared as follow, degenerative changes and disarrangement in the follicular cells & distribution of granulose cells in the follicular fluid .In the 2 nd. experimental group the histopathological changes was include , failure in development of the primary follicles into growing follicles & spread of granulose cells in the antrum within the follicular fluid , as well as vasculization of the follicular fluid & fibrosis was happened in some growing follicles , also the number of atretic follicles was found in the cortex of the ovary . | ||
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