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Assessment of the antidiarrhoeal activity of methanolic extract of Ceratonia siliqua fruit in rodents | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 2, Issue 1, 2009, Pages 1-8 PDF (160.55 K) | ||
| Author | ||
| Wisam H. S. AL-Shebani | ||
| Abstract | ||
| The methanolic extract of Ceratonia siliqua fruit was evaluated for its antidiarrhoeal potential activity in mice and rats. The methanolic extract of the fruit of this plant, at graded dose (250 and 500 mg/kg BW, p.o) was investigated by using three experimentally- induced diarrhea models, in order to understand the mechanism of its antidiarrhoeal activity. Models and castor oil- induced diarrhoea in mice, magnesium sulphate- induced diarrhea in mice, Charcoal meal test in mice and castor oil- induced enteropooling in rats. The extract at both doses showed a remarkable anti diarrhoeal activity evidenced by significant delay (P<0.01) in onset of diarrhea, decrease (P<0.01) in number of wet stools, total number of stools and total weight of fecal output in 4 hour in both the castor oil and magnesium sulphate models in mice. The extract also significantly (P<0.01) increased the intestinal transit time in characoal meal test in mice when compared to atropine sulphate (0.1 mg/kg BW, i.p). It also significantly (P<0.01) inhibited castor oil- induced enteropooling in rats compared to that of atropine sulphate standard drug, at dose of 3 mg/kg BW, i.p. The results of this study revealed that the methanolic extract of Ceratonia siliqua fruit contains pharmacologically active substance (s) with antidiarrhoeal properties. These properties may explain the rational for the effective use of the plant as antidiarrhoeal agent in traditional medicine. Further studies, however, are necessary to isolate and identify the active ingredients of Ceratonia siliqua fruit and their exact mode of action. | ||
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