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EXPRESSION OF Fas AND FasL IN TROPHOBLASTIC TISSUE OF WOMEN WITH SPONTANEOUS AND INDUCED ABORTION USING INSITU HYBRIDIZATION TECHNIQUE | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 9, Issue 2, 2011, Pages 147-151 | ||
| Authors | ||
| Abdul-Razzak H. Ahmed; Mohammed R. Ali | ||
| Abstract | ||
| Background Apoptosis of trophoblastic cells may play a role in the pathogenesis of abortion, and one mechanism of apoptosis is Fas receptor and legand system. Objective Estimate the level of Fas and FasL in trophoblastic tissue of aborted women. Methods In this study, 25 women with spontaneous abortion and 5 women with induced abortion were included from attendants of Gynecology department at Al-Kadhimiya Teaching Hospital in Baghdad. In-situ hybridization (ISH) tests were done to detect the level of expression of Fas and FasL in trophoblastic tissue. Results The highest percentage of expression of Fas and FasL was found in the trophoblastic tissue of females with spontaneous abortion (34.36% for Fas and 31.86% for FasL), while the expression of them was low in induced abortion group (9.2% and 9.4%, respectively). Conclusion The data strengthen the possibility that the apoptosis of trophoblastic cells via enhanced expression of Fas-FasL system is an important mechanism of spontaneous abortion. Key words Miscarriage, Trophblast, Apoptosis, Fas, FasL, ISH. | ||
| Keywords | ||
| Miscarriage; Trophblast; Apoptosis; Fas; FasL; ISH | ||
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