Shakir Magtoof, M., S. Hassan, Z. (2011). Synthesis and Characterization Of Some 3-Phenylthio/3-Phenoxyazetidine-2- One: Application of Two Dimensional NMR HMQC 1H-13C, Cosy 1H–1H And Mass Spectroscopy. , 0(41), 90-105.
Mahmood Shakir Magtoof; Z. S. Hassan. " Synthesis and Characterization Of Some 3-Phenylthio/3-Phenoxyazetidine-2- One: Application of Two Dimensional NMR HMQC 1H-13C, Cosy 1H–1H And Mass Spectroscopy". , 0, 41, 2011, 90-105.
Shakir Magtoof, M., S. Hassan, Z. (2011). ' Synthesis and Characterization Of Some 3-Phenylthio/3-Phenoxyazetidine-2- One: Application of Two Dimensional NMR HMQC 1H-13C, Cosy 1H–1H And Mass Spectroscopy', , 0(41), pp. 90-105.
Shakir Magtoof, M., S. Hassan, Z. Synthesis and Characterization Of Some 3-Phenylthio/3-Phenoxyazetidine-2- One: Application of Two Dimensional NMR HMQC 1H-13C, Cosy 1H–1H And Mass Spectroscopy. , 2011; 0(41): 90-105.

Synthesis and Characterization Of Some 3-Phenylthio/3-Phenoxyazetidine-2- One: Application of Two Dimensional NMR HMQC 1H-13C, Cosy 1H–1H And Mass Spectroscopy

Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 41, 2014, Pages 90-105
Authors
Mahmood Shakir Magtoof; Z. S. Hassan
Abstract
Abstract
This study is concerned with the synthesis and characterization of the 3–phenylthio/3-phenoxyazetidine-2-one 3(a-e). These compounds were prepared by phenylthio/phenoxyacetic acid (1) with the appropriate Schiff bases 2(a-d) in the presence of triethylamine with phosphorusoxychloride in dry methylene chloride under nitrogen atmosphere at 0˚C. The active acid chloride reacts with triethylamine to generate corresponding ketene in situ which further reacts with Schiff’s base to furnish corresponding 3–phenylthio/3-phenoxyazetidine-2-one 3(a-e) in moderate yields .
Keywords
Azetidin; ones; Antibiotics; ketene; phosphorusoxychloride; cosy nmr
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