Effect of deacetyl on Bacteria Isolated from Respiratory Tract

	Effect of deacetyl on Bacteria Isolated from Respiratory Tract
AL-TAQANI
Article 1, Volume 23, Issue 3, 2010, Pages 0-0
Abstract
Sixty one isolates were obtained from respiratory tract infections during the interval: March /2002 to January/2003. Samples were sputum (95%), throat swabs 1.6%, bronchial wash 3.3%. Most of the isolates were G-ve 88.5% and the rest were G+ve. Klebsiella represented the highest percentage among the G-ve 24%; followed by Moraxella catarrhalis, 22% then Escherichia coli 18.5%. Majority of isolates were resist to one or more antibiotics, some are resist to 7 antibiotics as in the Klebsiella isolate # 16A and Enterobacter isolate # 25, one of staphylococcal isolate # 19 was resist to 9 antibiotics. The effect of diacetyl on these isolates was studied by agar diffusion method using Muller-Hinton agar at 4 mm depth in Petri dish with 9 cm diameter. Diacetyl applied at 30, 60, 120, 180 g per 5mm diameter well of surface cultivated plates. Results revealed that most of the isolates were sensitive to diacetyl especially those resist to large number of antibiotics. G+ve bacteria showed some resistance 14.3% (one isolate out of seven); while G-ve showed only 1.7% (one isolate out of 54). The mechanism of diacetyl action has been discussed and suggestion for using diacetyl as aerosol for treatment of respiratory tract infections was put forward after completion of requirement for such use.

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