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The effect of different concentrations of surface active agent on the absorption of sulphamethoxazole and trimethoprim from rabbit ileum | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 1, 2008, Pages 5-15 | ||
| Author | ||
| Manal khalid abdul ridha | ||
| Abstract | ||
| A combination of sulphamethoxazol SMX and trimethoprim TMP is widly used in the treatment of various systemic infections . This investigation was carried out to see the effect of increasing concentration of surface active agents ( SAA ) used in suspensions on the absorption of both drugs from isolated rabbit ileum . The study was carried out at PH 7.4 and at 37°C . The SAA chosen were tween 80, sodium laurylsulphate ( SLS ), polyethylene glycole ( PEG400 ), and PEG4000 at a concentrations of 0.1%w/v , 1%w/v, 2%w/v and 15% w/v (Note : 15% was chosen for the purpose of the investigation not as a concentration for formulation ). It was found that the absorption of both drugs decreased as a function of increasing the concentration of the different SAA. | ||
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