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Aspartate aminotransferase [AST] activity exposed to selected cyclic organic compounds in liver diseases sera | ||
| AL-TAQANI | ||
| Article 1, Volume 23, Issue 3, 2010, Pages 49-58 | ||
| Authors | ||
| Atheer Awad Mehdi; Wesen Adel Mehdi | ||
| Abstract | ||
| Human serum AST activity was measured in vitro in sera for 45 normal persons,their age ranged between [9-35] years which showed mean about 8 U/L. The AST activity in 40 patients with liver diseases shows the activity ranged between [30-83]U/L, total serum bilirubin ranged between [1.6-7.5]mg/dl. The present study aims to examine the effect of different new organic compounds on the activity of AST in sera from normal and patients with liver diseases.AST activity was inhibited by four of these compounds however the other compounds affected as activator. The inhibitory effect of two different concentrations of the four compounds were studied, using five different concentrations of the substrate. The type of inhibition, Vmapp and ki were determined. The recovery percentage and inhibition percentage were calculated with the absence and with the presence of different concentrations of these compounds. | ||
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