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THE POSSIBLE ROLE OF PROGESTERONE AND IL-4 IN TROPHOBLASTIC TISSUE OF ABORTED WOMEN COMPARED WITH NORMAL PREGNANCY | ||
| AL-TAQANI | ||
| Article 1, Volume 23, Issue 3, 2010, Pages 99-105 | ||
| Author | ||
| Eman A. Abd | ||
| Abstract | ||
| Objective: Estimation of the immunohistochemistry expression of progesterone and IL-4 in trophoblastic tissue of aborted women compared with normal pregnancy and to find out whether or not the expression of these two marker in low level is associated with abortion. Methods: A technique utilizing immunohistochemistry was performed to detect and determine the immunohistochemistry expression of progesterone and IL-4 proteins using paraffin embedded sections of curettage samples obtained from 40 women, who were divided into two groups: 30 women with first trimester abortion (group 1) and 10 women with induced abortion (group 2). Result: The levels of the immunohistochemistry expression of progesterone and IL-4 were found to be a significant increased in group 2 as compared with group 1 (p<0.001), with a significant positive correlation between these two parameters (P<0.05) in studied groups. Conclusion: The data of this study demonstrated that progesterone might induce expression of IL-4 in trophoblastic tissue that lead to successful pregnancy; thus the low trophoblasts expression of progesterone and IL-4 in first trimester pregnancy might play a role in pathogenesis of pregnancy failure | ||
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