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Trophoblast-Expression of Interleukin-6 (IL-6) and Human Chorionic Gonadotropin (hCG) inWomen with Recurrent Abortion ComparedWith Normal Pregnancy | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 5, Issue 1, 2008, Pages 92-101 | ||
| Authors | ||
| Hussain A. Suraf; Al-Zubaidy A. Ghaith; Salman H. Amal | ||
| Abstract | ||
| We studied the estimation of IL-6 and hCG expression in immunohistochemistry in women with unexplained Recurrent Spontaneous Abortion (RSA) and find out whether or not IL-6 regulates human Chorionic Gonadotropin release (hCG). An immunohistochemistry technique was performed to detect and determine the immunohistochemistry expression of IL-6 and hCG proteins using paraffin embedded sections of curettage samples obtained from 50 women, who were divided into three groups: 25 women with RSA, 15 women with abortion for the first time, and 10 women with induced abortion. The levels of the immunohistochemistry expression of both IL-6 and hCG were found to be highly significant increased in group 3 as compared with group 1 and group 2 (P<0.001), with a significant positive correlation between these two parameters (P<0.05) in three groups.The trophoblasts expression of IL-6 might play a role in stimulation of the expression of hCG during pregnancy. | ||
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