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THE EFFECT OF CRUDE PLANTAGO MAJOR LEAVES EXTRACT ON CYTOGENETIC OF HUMAN LYMPHOCYTES | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 51, Issue 3, 2010, Pages 360-368 | ||
| Authors | ||
| Shatha Ali Shafiq; Raghad Deah Abdul Jalill Al-shybany | ||
| Abstract | ||
| The results revealed the reduction effect of Mitotic Index and Blast Index by higher concentration after 1 hr. exposure time significantly but all of the lower concentration showed none significant changes on them. The same result was indicated when cells treated with exposure 10µg/ml of extract for 48h; BI was decrease. The extract has no toxic effect on lymphocyte at concentration 1 and 10µg/ml for 48h of treatment. After 72h of exposure time BI was significantly decreased while different values in MI were seen when cells treat with 1-100 µg/ml of extract. Moreover mitosis was inhibited at high concentrations of extract. The effect of crude extract on human lymphocyte without mitogen (PHA) was studied at different exposure time showed no mitosis. Using different concentrations of crude extract in replacement of colchicin showed mitotic cell without any significance in comparison with control. Maximum mitotic index and blast index were appeared in 100µg/ml of crude extract (5.418, 39.824) respectively. | ||
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