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chlorpromazine , determination, 2,2`-bipyridyl, spectrophotometry | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 22, Issue 4, 2011, Pages 79-93 PDF (0 K) | ||
| DOI: 10.33899/rjs.2011.31510 | ||
| Author | ||
| Wael A. Abdullah | ||
| Abstract | ||
| This paper describes the development of a spectrophotometric method for the determination of chlorpromazine hydrochloride drug via oxidation reduction method which based on the reduction of iron (III) by the chlorpromazine hydrochloride to iron(II) which gives a soluble colored complex when reacts with the reagent 2,2`-bipyridyl at room temperature having maximum absorption at 521 nm against reagent blank. Beer´s law was obeyed over the concentration range of 2.5 to 300 µg/25 ml with an apparent molar absorptivity of 1.054 x 104 l.mol-1cm-1 and Sandell`s sensitivity of 0.033 µg.cm-2. The relative error is ranged from -0.1 to -1.66% and relative standard deviation from ±0.2 to ±1.37% . The method has been applied successfully to the determination of chlorpromazine hydrochloride in two dosage forms : tablets and ampoules. Additives and excipients normally found in dosage forms do not interfere | ||
| Keywords | ||
| Spectrophotometric Determination of Chlorpromazine Hydrochloride Using Oxidation Reduction Method based on Reaction of Iron; Bipyridyl Reagent | ||
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