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SERUM LEVELS OF INTERLEUKIN-1 ALPHA AND INTERLEUKIN-6 IN ACUTE CORONARY SYNDROME PATIENTS | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 9, Issue 3, 2011, Pages 281-284 | ||
| Authors | ||
| Kismat M Turki; Mohammed O Hamzah | ||
| Abstract | ||
| Background Cytokines are responsible for the modulation of immunological and inflammatory processes and play a significant role in the pathogenesis of acute coronary syndrome patients (ACS). Objective This study aims to investigate the serum levels of IL-1α and IL-6 in ACS patients. Methods The study covered 140 subjects. It comprised a total of 101 patients with ACS patients [62 with acute myocardial infarction (AMI) and 39 with unstable angina (UA)], compared with 39 healthy individuals with no history of cardiac disease. Serum IL-1α and IL-6 analysis was performed by ELISA. Results The present results revealed that there were significant elevation in mean serum levels of IL-1α and IL-6 in patients with ACS ( AMI and UA) as compared to healthy control (P<0.001). Moreover, the levels of these cytokines were significantly higher in AMI patients when compared to UA patients (P<0.001). Conclusion These finding suggest that IL-1α and IL-6 play an important role in pathogenesis of ACS. Keywords Acute coronary syndrome, IL-1α and IL-6. | ||
| Keywords | ||
| Acute coronary syndrome | ||
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