Hassan Abood, Z., Delol Hanoon, H., Aziz Marhoon, A. (2010). Synthesis of Some New 1,3,4-Oxadiazole Derivatives from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone. , 0(38), 385-406.
Zaid Hassan Abood; Haitham Delol Hanoon; Ashraff Aziz Marhoon. "Synthesis of Some New 1,3,4-Oxadiazole Derivatives from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone". , 0, 38, 2010, 385-406.
Hassan Abood, Z., Delol Hanoon, H., Aziz Marhoon, A. (2010). 'Synthesis of Some New 1,3,4-Oxadiazole Derivatives from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone', , 0(38), pp. 385-406.
Hassan Abood, Z., Delol Hanoon, H., Aziz Marhoon, A. Synthesis of Some New 1,3,4-Oxadiazole Derivatives from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone. , 2010; 0(38): 385-406.

Synthesis of Some New 1,3,4-Oxadiazole Derivatives from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4-methoxy phenyl] methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone

Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 38, 2014, Pages 385-406
Authors
Zaid Hassan Abood; Haitham Delol Hanoon; Ashraff Aziz Marhoon
Abstract
Abstract
In this research new tri(1,3,4-oxadiazole) derivatives [5-10] were prepared starting from 4-{bis[3-(5-mercapto-1,3,4-oxadiazol-2-yl)-4- methoxyphenyl]methylene}-2-(5-mercapto-1,3,4-oxadiazol-2-yl)cyclohexa-2,5-dienone [4].
The triester derivative [2] obtained from treatment of 5,5'-[(3-carboxy- 4-oxocyclohexa-2,5-dienylidene)methylene]bis(2-hydroxybenzoic acid) [1] with dimethyl sulphate in presence of anhydrous sodium carbonate in dry acetone which was then converted into the trihydrazide derivative [3] by reaction with hydrazine monohydrate in absolute ethanol. Treatment of trihydrazide derivative [3] with carbon disulfide in presence of potassium hydroxide in absolute ethanol resulted in the formation of tri(1,3,4-oxadiazole) derivative [4] which was then converted into the trithioalkyl derivatives [5], [6] and [7] by reaction with benzyl chloride, n-butyl bromide and n-propyl bromide in basic medium, respectively. Treatment of trithioalkyl derivatives [5], [6] and [7] with potassium permanganate in acidic medium resulted in the formation of trisulfone derivatives [8], [9] and [10], respectively. These new synthesized compounds [2-10] probably have some biological activity.
All new compounds were characterized by melting points and were uncorrected, (C.H.N.) Elementary Analysis and FT-IR spectra.
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