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A Combination of Clomifene Citrate (CC) and L-Carnitine (LC) Significantly Reduces Spermatozoal Lipid Peroxidation (LP) in Obese Male Idiopathic Subfertile Normozoospermic Patients | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 8, Issue 4, 2011, Pages 545-555 | ||
| Authors | ||
| Najah R. Haddi; Noorhan Shakir Mhao; Ahmed S. Al-Hilli | ||
| Abstract | ||
| Objective: To study the effect of a combination of CC and LC in decrease of spermatozoal LP and improvement sperm quality in obese male idiopathic subfertile normozoospermic patients. Design: A prospective study. Setting: Maternity and Childhood hospital. Patient and Method(s): 35 proven obese male idiopathic subfertile normozoospermic patients were given CC and LC for 3 months ,10 subfertile patient did not received any medication except placebo.10 healthy proven fertile man served as control volunteers group. Their semen analyses and spermatozoal Malondialdehyde (MDA) assay were carried out as an index of spermatozoal LP before and after course of treatment. Results: There is high statistically significant differences (P<0.05) in mean of MDA concentration in post-treated group when compared to non-treated group of obese male idiopathic subfertile patients and control group. Significant increase (P<0.05) in sperm vitality in combination post-treated group when compared to non-treated group of obese male idiopathic normozoospermic subfertile patients and control group. Conclusion(s): This study suggests that a combination of CC and L-C reduced spermatozoal lipid peroxidation (MDA) with improving sperm vitality in obese male idiopathic subfertile normozoospermic patients. | ||
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