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Double Combination of Some Antibiotics Against Local Isolate of Methicillin Resistant Staphylococcus aureus (MRSA) | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 8, Issue 1, 2011, Pages 22-25 | ||
| Authors | ||
| ; S. N; J. H; | ||
| Abstract | ||
| We compared in this study the in vitro potency of some antibiotics when used singly and in combination against the multi-drugs resistant Staphylococcus aureus using the wells diffusion in agar. Rifampin, vancomycin, tetracycline and trimethoprim-sulfamethoxazole were randomly selected for this study. The isolate of S. aureus used in this study was previously characterized in our laboratory as methicillin-resistance Staphylococcus aureus-MRSA carrying the mec-A gene which is responsible for methicillin resistance. Tremendous potencies were observed when the antibiotics used in combination compared with each antibiotic alone. The inhibition zone of vancomycin plus rifampin was 28 mm. in diameter compared with 18 mm. and zero (fully resistance) for vancomycin and rifampin respectively. Like rifampin, trimethoprim-sulfamethoxazole was inactive per se, since no inhibition zone was seen but when combined together, the inhibitory action significantly increased up to 19 mm. in diameter. Furthermore, combination of tetracycline with trimethoprim-sulfamethoxazole scored an inhibition zone as high as 43 mm. compared with 30 mm. for tetracycline alone | ||
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