Prophylactic Effects of Melatonin in Lead Induced Toxicity in Rats

Alwakeel, Nazar; Hussain Ali, Shatha; Abdul-Rehman Hussin, Saad; Ghazi Alabbassi, Mustafa

	Prophylactic Effects of Melatonin in Lead Induced Toxicity in Rats
Al-Mustansiriyah Journal for Pharmaceutical Sciences
Article 1, Volume 6, Issue 1, 2009, Pages 157-173
Authors
Nazar Alwakeel; Shatha Hussain Ali; Saad Abdul-Rehman Hussin; Mustafa Ghazi Alabbassi
Abstract
Exposure to lead results in significant accumulation in most of vital organs, and free radical damage has been proposed as a cause of lead-induced tissue damage where oxidative stress is a likely molecular mechanism. This study is designed to evaluate therapeutic effects melatonin in lead-induced organs toxicity in rats. Evaluation of melatonin in this respect was conducted in a rat model of lead-induced toxicity. All test groups here were challenged with subcutaneous injections of 100mg/kg lead acetate daily for one month. Melatonin in a dose of 20 mg/kg was administered intraperotoneal as adjunct treatment with lead acetate. The changes in total body weight, weight of major organs (brain, liver and kidney), oxidative stress parameters, hemoglobin content, liver and renal functions, and histological appearance of the studied organs were evaluated and compared with that of negative and positive controls. In addition, melatonin has the ability to reverse the damage induced by lead in many organs and tissues through the reduction of MDA levels in RBCs, brain, liver and kidney; and the increase in GSH levels in all studied organs; in addition to the improvement in the indices of the functions of the organs studied. These findings demonstrate that melatonin capable of preventing damage of rat tissues caused by successive doses of lead acetate, and also demonstrate that these animals had restored their organ functions due to treatment with melatonin.

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