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Enkephalin Leucine Microspheres Suspension as a Sustained Antiplaque Antimicrobial Delivery System | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 7, Issue 1, 2010, Pages 30-42 | ||
| Authors | ||
| H. Samein; | ||
| Abstract | ||
| The purpose of this study is to prepare a formulation containing enkephalin leucine as an antiplaque/antibacterial agent. Enkephalin leucine microspheres were prepared using a poly(D-L-lactide-co-glycolide) (PLGA) as a delivery system. The microspheres were prepared by a dispersion/solvent extraction-evaporation method and characterized for drug load by HPLC, particle size by laser diffractometry and surface morphology by scanning electron microscopy (SEM). In vitro enkephalin leucine release was studied using a dialysis method. The stability of peptide in human saliva was concentration dependent. PLGA microspheres had released after socking in the artificial saliva. The encapsulation efficiency was around 83% -97% with the spherical shape. The in vitro release was successfully controlled over 60 minuteor more with percentage of release reach to 70% for the free drug & 25% for the adsorbed drug. | ||
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