S. S, E., M. T, K., H. M, M. (2010). The role of chloroquine phosphate on tumor necrosis factor - alpha and interleukin-one in knee osteoarthritic patients. , 8(2), 15-21.
Eman S. S; Kismet M. T; Mohammed H. M. "The role of chloroquine phosphate on tumor necrosis factor - alpha and interleukin-one in knee osteoarthritic patients". , 8, 2, 2010, 15-21.
S. S, E., M. T, K., H. M, M. (2010). 'The role of chloroquine phosphate on tumor necrosis factor - alpha and interleukin-one in knee osteoarthritic patients', , 8(2), pp. 15-21.
S. S, E., M. T, K., H. M, M. The role of chloroquine phosphate on tumor necrosis factor - alpha and interleukin-one in knee osteoarthritic patients. , 2010; 8(2): 15-21.

The role of chloroquine phosphate on tumor necrosis factor - alpha and interleukin-one in knee osteoarthritic patients

Al-Mustansiriyah Journal for Pharmaceutical Sciences
Article 1, Volume 8, Issue 2, 2010, Pages 15-21
Authors
Eman S. S; Kismet M. T; Mohammed H. M
Abstract
Osteoarthritis (OA) is a condition characterized by a series of
inflammatory processes. Various pro inflammatory cytokines like interleukin–
one (IL-1) and tumor necrosis factor–alpha (TNF-α) are present in synovium
and tissue of rheumatic patients, so these agents play an essential role in
pathogenesis of joint diseases. Chloroquine phosphate (CQP) interferes the
cellular function of acid microenvironments such as lysosome, endosome and
Golgi's complex, as well as affects pathways of inflammation, immune cascade
and enzyme activity which ultimately resulted in cartilage destruction in knee
joint with OA.
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