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Comparative study for the dissolution of Isosorbide dinitrate tablets in commercial products | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 9, Issue 1, 2011, Pages 7-12 | ||
| Author | ||
| Kahtan J. Hasson | ||
| Abstract | ||
| Isosorbide dinitrate is prepared as a solid dosage forms, and found in the market as a sublingual tablet or conventional tablet of 10mg for oral administration which is subjected to the dissolution study. In this present work, different commercial products of Isosorbide dinitrate tablets were subjected to dissolution test according to USP method which includes an HPLC determination. The dissolution profiles of three commercial products of isosorbide dintrate tablets and preformulated product were evaluated by comparing with that of reference standard (European product. Actavis Co.) . Due to low bioequivalenceis of all the commercial products relative to the reference standard, attempts were made to improve the formula of the experimental batch of isosorbide dinitrate tablet by enhancing the dissolution rate and increase the stability of the active substances via the Using of a direct compression method in manufacturing of isosorbide dinitrate tablet which on testing showed a high dissolution rate with optimal physical properties of tables. | ||
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