Immunohistochemical Study of CEA and BCL2 Expression in Colorectal Adenocarcinoma and its Correlation with Some Pathological Parameters

Baqer Hussein Al-Harmooshy, Maather

	Immunohistochemical Study of CEA and BCL2 Expression in Colorectal Adenocarcinoma and its Correlation with Some Pathological Parameters
Medical Journal of Babylon
Article 1, Volume 8, Issue 2, 2011, Pages 243-252
Author
Maather Baqer Hussein Al-Harmooshy
Abstract
Background :- Colorectal cancer is the second most prevalent cancer and the fourth leading cause of death[1]. In Iraq and according to the Iraqi cancer registry reports in 2002 , the incidence of colorectal carcinoma was 4.55% of whole body malignancy, & it is the seventh cause of death from cancer[3]. Immunohistochemical studies have revealed that CEA is a product of normal as well as cancerous colonic cell and that the difference in CEA content between the cancerous and the normal colorectal mucosa is quantitative and not qualitative[9-11], Expression of bcl-2 has been studied in a number of human tumors, including colorectal carcinoma. Non-small-cell lung carcinomas[18] breast carcinomas[19,20] and neuroblastomas[21] all express bcl-2, and studies have been published correlating expression with survival. Similarly, a number of studies[22-26] have been published evaluating the clinical use of bcl-2 immunohistochemical expression as a prognostic factor. Aim of the study :- The aim of our study was to estimate possible correlations between the CEA and BCL-2 immunohistochemical expression and some pathological parameters in colorectal adenocarcinoma like grade , stages and site of tumor Material and method: - thirty nine patients of colorectal carcinoma studied in Al- Diwanyia teaching hospital during a three years period (July 2008 - December 2010) were studied. There were 30 males and 9 females with a median age of 58 years (range 26-90 years). A manual avidine-biotin-peroxidase complex procedure was used in the immunohistochemical analysis (DakoCytomation, Copenhagen, Denmark). Result :- all the studied cases were positive for CEA (100%) and out of 39 cases there were only 23(58.9%) cases positive for BCL2 expression , also this study showed significant relationship between expression of CEA and grades and site of tumor while BCL2 significantly correlated with grades and stages of the tumor. Conclusion :- From the present study we may conclude that CEA and BCL-2 have a similar pattern of expression in primary colorectal adenocarcinoma although BCL-2 expression in colorectal adenocarcinoma is more restricted than CEA expression

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