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HISTOLOGICAL EFFECTS OF MELATONIN ON MALE RAT'S ALVEOLAR MACROPHAGES | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 6, Issue 2, 2008, Pages 29-35 | ||
| Authors | ||
| Salman S. Salman; Ali Hani Abd; Samia A. Eleiwe | ||
| Abstract | ||
| Background: Melatonin is a neuro-hormone of the pineal gland. It increases and enhances immunity, whether in animals or human. The mononuclear – phagocyte system; is a single functional immune unit. The pulmonary alveolar macrophages are one of the most important members included within this immune unit. Objective: This work tried to study the effect of different doses of dietary melatonin on adult rat's pulmonary alveolar macrophages. Methods: Melatonin was supplied to adult rats, for successive 30 days. Rats were divided into 6 groups. Group I was the control. Group II, III, IV, V and VI were given a daily dose of melatonin as 125, 250, 500, 750 and 1000 µg / kg body weight, respectively. After the last day of treatment, the left lung of the rat was removed under anesthesia for histological study. Results: The results showed significant beneficial effects on pulmonary alveolar macrophages by normal therapeutic dosages, whereas with further stepping up doses, significant damaging effects were seen. Conclusion: Dietary melatonin had good effects on the rat's pulmonary alveolar macrophages within therapeutic doses, whereas it had highly damaging changes in overabundance. | ||
| Keywords | ||
| Melatonin; immunity; alveolar macrophages | ||
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