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BCL-2 OVEREXPRESSION IN COLORECTAL CARCINOMA | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 6, Issue 2, 2008, Pages 66-76 | ||
| Author | ||
| Alaa Ghani Hussain | ||
| Abstract | ||
| Background: Colorectal cancer is a major cause of morbidity and mortality worldwide. Prognostic assessment influences the treatment of patients with colorectal cancer, including decisions about adjuvant therapy. Bcl2 over-expression is a genetic event associated with tumor progression and is a prognostic marker of this disease. Objective: Colorectal carcinoma is a major cause of morbidity and mortality worldwide. Bcl2 overexpression is a genetic event associated with tumor progression and is a prognostic marker for this disease. The aim of this study is to assess the expression of bcl2 in colorectal carcinoma and its correlation with other clinicopathological parameters. Methods: From January 2004- January 2005, thirty –five formalin fixed paraffin embedded tissue samples from patients with colorectal carcinoma were included in this study. Four-micrometer tissue sections were obtained for each case, two of them were stained by H&E and the diagnosis had been revised, and the other two were stained immunohistochemically by using avidin biotin alkaline phosphatase method for evaluating bcl2 expression. The presence of red cytoplasmic staining in less than 25% of tumor cells was considered a positive expression of bcl2. Statistical analysis of all the results were performed using Chi square test at level of significance alpha = 0.05 (P<0.05) regarded as statistically significant. Results: Bcl2 expression was significantly higher in low grade and early stage colorectal carcinoma .Non mucinous colorectal cancer showed more bcl2 expression than the mucinous type. An inverse correlation was found between bcl2 expression with the greatest diameter of the tumor and the lymph node status. Bcl2 expression was correlated neither with the age nor with the sex of the patient and the tumor location. Conclusion: Bcl2 over-expression correlates with many variables as low grade colorectal tumor, early stage, non mucinous type, small tumor size and negative lymph node status. | ||
| Keywords | ||
| bcl; colorectal carcinoma | ||
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