Bladder Preservation by Transurethral Resection and Radiotherapy in Invasive Bladder Cancer

Hussin, Ahmed; Mutter, Adnan

	Bladder Preservation by Transurethral Resection and Radiotherapy in Invasive Bladder Cancer
Medical Journal of Babylon
Article 1, Volume 8, Issue 3, 2011, Pages 381-393
Authors
Ahmed Hussin; Adnan Mutter
Abstract
Purpose: We evaluate the use of a transurethral resection with radiotherapy in the treatment of operable transitional cell carcinoma of the bladder with potential bladder preservation. Materials And Methods: A total of 143 consecutive patients with T2-T3 bladder tumors underwent as complete transurethral resection as possible. They then received radiation therapy for 6-7 weeks. Following that, patients were reevaluated cystoscopically and ultrasound imaging. Of the 143 patients 92 have complete clinical response, undergo 3-6months cystoscopic examination for two years. 48 Patients had incomplete responses. Results: Of the 143 patients 92 had no detectable tumor after induction therapy. 48 Patients who had incomplete responses, 11 of them were undergo an immediate radical cystectomy. 3 patients die during period of radiotherapy, and 12 patients, die during period of follow up and treatment. The mean age of our patients was 57 years, 106 male patients and 37 female patients Conclusions: This study demonstrates a high rate of response to this combined radiation regimen in conjunction with a visibly complete transurethral resection. The results of bladder sparing approach for the treatment of muscle-invasive bladder cancer, using a combination of transurethral resection (TUR) and radiotherapy, are encouraging and increase the survival of patients treated by this method.

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