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CD38 EXPRESSION ON PERIPHERAL T AND B LYMPHOCYTES IN NEWLY DIAGNOSED T1DM CHILDREN | ||
| IRAQI JOURNAL OF MEDICAL SCIENCES | ||
| Article 1, Volume 6, Issue 3, 2008, Pages 42-46 | ||
| Authors | ||
| Nidhal Abdul Mohymen; Eman M. Saleh | ||
| Abstract | ||
| Background: In Type 1 Diabetes Mellitus (T1DM), numerous changes in the cellular as well humoral immune response have been identified. However, it is not known whether both the CD4+ and CD8+ subpopulation or only one of these or CD19+ contains increased numbers of activated cells. Objective: The aim was investigate the expression of CD38 as activated marker on the peripheral blood lymphocytes of T1DM children at the onset of the disease. Patients and methods: A total of 60 T1DM patients who were newly onset of the disease (diagnosed less than five months) were included in the present study, all the patients were treated with daily replacement doses of insulin. Fifty apparently healthy control subjects underwent the peripheral blood lymphocytes (PBL)phenotyping. Phenotyping of surface antigens was done by direct Immunoflurocent (IF)technique using mouse antihuman CD38. Results: Increased percentage of activation marker CD38+ cells were observed in T1DM patients (24.72%, 23.83%) as compared with the control group (16.86%, 15.97%) in the age group ≤10 years and >10 years old respectively. These differences were highly significant (P1=0.0001) between the patients and healthy individuals, but failed to reach a significant level (P2= 0.44)between the patients in both age groups. Conclusion: A significant elevated percentage of CD38+ activation marker cells were detected in the patients. | ||
| Keywords | ||
| Immunophenotyping | ||
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