RUBELLA POST – VACCINATIONAL ANTIBODY RESPONSE AMONG RUBELLA - SERPOSITIVE INDIVIDUALS

Ibrahim Latif, Ismail

	RUBELLA POST – VACCINATIONAL ANTIBODY RESPONSE AMONG RUBELLA - SERPOSITIVE INDIVIDUALS
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 6, Issue 3, 2008, Pages 99-103
Author
Ismail Ibrahim Latif
Abstract
Background: Rubella is an acute febrile illness that affects children and young adults. However, infection during early pregnancy may result in serious abnormalities of the fetus. Live attenuated vaccine controls rubella infection in industrialized countries. Objective: To determine the antibody response to rubella virus in seropositive volunteers after vaccination with live attenuated rubella vaccine. Methods: Fifty two rubella virus seropositive volunteers have been included in the study, their ages ranged between 15-45 years. 26 of them were vaccinated with rubella vaccine and the rest were injected with diluent supplied with the rubella virus vaccine (placebo). Antibodies against rubella virus were detected in volunteer's sera prior to, one and four weeks after vaccination, using ELISA method. Results: There was elevation in the serum antibodies after vaccination. The Optical Density (OD) readings were 1.69 and 2.02 during first and fourth week respectively. Data analysis showed that there was a significant difference of OD value among seropositive vaccinee. And there was a significant elevation of serum antibody in the first week, but the fourth week had very high OD readings, which may reflect an increase in the concentration of antibodies. Conclusion: Rubella vaccine was safe, and effective, and there was an elevation in serum antibody titer among vaccinee.
Keywords
Rubella vaccination; IgG antibody; seropostive individuals

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