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Synthesis of New Heterocyclic Compounds Derived from 4-Amino Antipyrine | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 42, 2014, Pages 217-227 | ||
| Authors | ||
| Mustafa K. Toema; Iyad S. Hameed; Redha I. Al-Bayati | ||
| Abstract | ||
| Abstract In this work, isondoline -1,3-dione derivatives [2-5] were prepared from the corresponding anhydrides and 4-amino antipyrine [1].Derivatives[6-11] containing urea and thioureamoieties at position [4]were prepared from 4-amino antipyrine[1] and an appropriatearyl or alkyliso or (isothio)cyanates and then converted into pyrimidine derivatives [12-15]. Treatment of compound [1] with formic acid or acetic acid give the amide derivatives [16 and 17], which upon refluxing of compound [16]) with hydrazine hydrate in ethanol yielded the corresponding 2,3-dimethyl-1-phenyl-2,4-dihydro-1H-pyrazolo[4,3,e][1,2,4]-triazine [18]. Reacting compound [1] with acetyl acetone in boiling ethanol for 6hrs, leads to 4-amino antipyrine derivative [19]. The azomethines[20-22] were prepared from the corresponding aryl aldehydes and compound [1]. | ||
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