Evaluation of Serum Cholinesterase Activity, Lipid Peroxidation and Lipids Profile in Type 2 Diabetes Mellitus

Abdel Nabi  Awad, Nadhum; M. Yasser, Oda; Mohammed Jewad, Abdulkareem

	Evaluation of Serum Cholinesterase Activity, Lipid Peroxidation and Lipids Profile in Type 2 Diabetes Mellitus
Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 42, 2014, Pages 261-282
Authors
Nadhum Abdel Nabi Awad; Oda M. Yasser; Abdulkareem Mohammed Jewad
Abstract
Abstract The study was designed to evaluate serum cholinesterase activity, lipid peroxidation, lipids profile and nitric oxide production, in sera of diabetes type 2 and the control group to show whether there are changes in their levels. The results of this study showed significant elevations (P< 0.001) in each of serum cholinesterase and lipid peroxidation end product represented by serum MDA concentrations in type 2 diabetic patients as compared to control group. Although, this study showed a non-significant elevation in serum nitrite, the nitrate was elevated significantly (P< 0.001) in diabetic type 2 patients as compared to control group. The lipids profile of diabetic type 2 patients showed significant changes represented by significant elevations (P< 0.001) in each of TG, t. cholesterol, LDL and VLDL, and a significant decrease (P< 0.001) in HDL as compared to control group. Using regression analysis showed a significant positive correlation between serum cholinesterase (P< 0.001) and each of FBS (r = 0.698), MDA (r = 0.69), NOx (r = 0.51), t. cholesterol (r = 0.487), TG (r = 0.691), LDL (r = 0.575), and VLDL (r = 0.455), and a significant negative correlation(P< 0.001) with HDL (r = - 0.861). Conclusion can be made that diabetes mellitus is a low grade systematic inflammation associated with high oxidative stress, lipid peroxidation and serum cholinesterase activity, which may in turn, affect lipoproteins metabolism.

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