- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
SERUM CONCENTRATION OF INTERLEUKIN -1α AND INTERLEUKIN-8 ASSOCIATED WITH ABSOLUTE MONOCYTE COUNT IN PATIENTS WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)* | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 52, Issue 2, 2011, Pages 0-0 | ||
| Authors | ||
| Mohammed S. Abbas; Ali M. Jawad; Jassem T. Alkhafaji; Ghaneima S. Muhammed; Kasim Sh. Al-Mayah; Muhammed A. Al-Dabagh | ||
| Abstract | ||
| Interleukin-1α( IL-1α) and interleukin 8 (IL-8) have a major role in initiation of immune response. These two cytokines are secreted mainly by monocyte. This study aimed to evaluate the initiation of immune response in patients with acute lymphoblastic leukemia. Blood samples were collected from 36 patients with ALL (26 treated and 10 untreated ). Other 10 blood samples were collected from healthy individuals as control group. Enzyme linked immunosorbent assay (ELISA) was used to estimate serum concentration of IL-1 and IL-8. Absolute monocyte count in each blood sample was determined. The study showed a significant decrease in serum concentration of IL-1α in treated and untreated patients, whereas, serum concentration of IL-8 and blood absolute monocyte count showed significant increase in untreated patients. Dropping in IL-1α and elevation of IL-8 with increasing absolute monocyte count may indicate suppression of gene expression for IL-1 but not for IL-8. | ||
|
Statistics Article View: 22 PDF Download: 6 |
||