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Prognostic Significance of Troponin T and Creatine Kinase-MB Activity in Sera of Acute Ischaemic Stroke Patients | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 7, Issue 3, 2010, Pages 469-479 | ||
| Authors | ||
| Ala Hussain Abbase Haider; Dheya Kazim Al-Khefaji | ||
| Abstract | ||
| Background and purpose: Elevation of sera cardiac troponin T (cTnT) concentration and creatine kinase-MB (CK-MB) activity and electrocardiographic changes can occur after ischaemic stroke. The aim of this study was to identify the relation ships between elevated cardiac biochemical markers with ECG changes , stroke severity and in-hospital mortality and to look for source of CK-MB. Patients and method: From 1 June 2009 to 1 October 2009 this study recruited 70 patients (46 males , 24 females ) who were admitted to Merjan teaching hospital due to acute ischaemic stroke which confirmed by neurologist , blood samples were taken for cTnT and CK-MB measurement and ECG was done. The stroke severity as assessed by Scandinavian stroke scale, and in hospital death were compared between the two groups of the cTnT and CK-MB. Hypertension and diabetes were separately compared between two groups of cTnT and CK-MB Results: Sera cTnT concentration and CK-MB activity were elevated in 22.9% , 35.7% of cases respectively . ECG changes occured in 45.7% . In contrast to elevated CK-MB activity, elevated cTnT associated with greater stroke severity and in hospital deaths .ECG changes were more in patients with elevated cTnT than in patients with elevated CK-MB. CK-MB was not elevated in most patients with elevated cTnT, the non parallel increase of CK-MB with cTnT signify the non cardiac source of CK-MB . Hypertension and diabetes mellitus were more common in the elevated cTnT patients than normal cTnT group. Conclusion: Elevated sera cTnT in patients with acute ischaemic stroke were associated with severe neurological deficits and in hospital deaths. The elevated CK-MB was mostly non-cardiac source and not correlated with stroke severity and in hospital death. The elevated cTnT along with ECG changes , hypertension and diabetes mellitus signify underlying asymptomatic coronary artery disease. | ||
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