Hepatoprotective Potentials of Nebivolol and Aliskiren on   Methotrexate Induced Liver Toxicity

Irheim Mohammad, Bassim

	Hepatoprotective Potentials of Nebivolol and Aliskiren on Methotrexate Induced Liver Toxicity
Medical Journal of Babylon
Article 1, Volume 7, Issue 3, 2010, Pages 563-570
Author
Bassim Irheim Mohammad
Abstract
Background: Oxidative stress has been implicated as important cause of Methotrexate (MTX) induced liver toxicity. Recently nebivolol and aliskiren have been described to posses antioxidant properties. Objective: This study was designed to investigate the hepatoprotective potentials of Nebivolol and Aliskiren on MTX induced hepatotoxicity. Materials and methods: A total of 32 rabbits were randomized into 4 equal groups. Group 1 received no treatment (control) while group 2,3 and 4 received MTX, MTX+Nebivolol or MTX+Aliskiren respectively for 8 weeks. At the end of 8 th week all animals were sacrificed and liver function tests (SGOT, SGPT, ALP, bilirubin, TSP and PT) were measured. Liver tissues were used for measurement of MDA and GSH levels and for histopathological evaluation. Results: MTX treatment caused significant impairment in liver function profile. MTX also induced significant increase in MDA and significant decrease in GSH levels in liver tissues. Nebivolol and aliskiren significantly improved liver function profile. Both drugs also reduced MDA levels and elevated GSH levels. Furthermore hisological evaluation of liver sections confirmed the hepatotoxicity of MTX and the improvement with the combination treatment of nebivolol or aliskiren. These findings suggested that both drugs have promising hepatoprotective potential against MTX induced liver toxicity.

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