Evaluation of EBV serum and salivary IgA antibodies level in head and neck cancer patients

Sahib Abdulamir, Ahmed

	Evaluation of EBV serum and salivary IgA antibodies level in head and neck cancer patients
Iraqi Postgraduate Medical Journal
Article 1, Volume 5, Issue 2, 2006, Pages 209-212 PDF (0 K)
Author
Ahmed Sahib Abdulamir
Abstract
ABSTRACT: BACKGROUND: Many previous studies revealed that salivary and serum IgA response to infectious agents such as EBV-coded antigens in patients with nasopharyngeal carcinoma (NPC) had a vital role in the combat against tumorigenesis. Moreover, it could be considered as a reliable index for the humoral limb of anti-cancer immunological action. METHOD: One hundred twenty two head and neck cancer (HNCA) patients were selected randomly from two main hospitals, Alkadhimya hospital and radiotherapy center in Baghdad. Also 100 apparently healthy control subjects (HC) underwent the same examinations and tests. Enzyme-linked immunosorbent assay (ELISA) test was applied on all HNCA patients sera and saliva, in order to measure anti-EBV IgA antibodies . RESULTS: Revealed that NPC patients were the only group that showed a sero-positive ELISA readings of anti- EBV serum IgA. No saliva EBV antibodies were detected in the studied groups . CONCLUSIONS: S.IgA level seems to be an applicable index for evaluating EBV burden originated from nasopharyngeal cancerous cells. Such index might help in diagnosing early and specifically the carcinogenesis of NPC, moreover, might help in evaluating the progress of the disease.
Keywords
Head and neck cancer; HNCA; nasopharyngeal carcinoma; NPC; immunosuppression

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